This antibiotic resistance reversal may be attributed to the elimination of R-plasmids as the multiple antibiotic resistance genes are usually located on R-plasmids. Active biomolecules from P. longum may prove to be a source to develop MDR reversal agents of natural origin to contain the development and spread of plasmid borne multiple antibiotic resistance. Key words: Antibiotic resistance.
Antibiotic cycling, whereby different antibiotics are prioritized and restricted through time, can lead to the reversal of resistance if resistant microbes pay the price for their abilities to.
The transmission dynamics of antibiotic-resistant bacteria: the relationship between resistance in commensal organisms and antibiotic consumption. Austin DJ, Kakehashi M, Anderson RM Proc Biol Sci, 264(1388):1629-1638, 01 Nov 1997.The many factors contributing to the present worldwide status of antimicrobial resistance are reviewed in this Series paper, with a particular focus on emergence of resistance, transmission, bacterial fitness, and potential for reversibility. The evidence for, and the role of, important drivers of antimicrobial resistance are considered and assessed in the context of the community (including.Antibiotic resistance may well predate the human exploitation of antibiotics. Similar mechanisms may be operating in the reversal of resistance when antibiotics disappear from the host environment. This review, with its more up-to-date collection of studies, more rigorously collected data (from only prospective studies) and more precise time frames (which avoid the uncertainty implicit in.
PDF; ABSTRACT. Pathogen resistance to antibiotics is a rapidly growing problem, leading to an urgent need for novel antimicrobial agents. Unfortunately, development of new antibiotics faces numerous obstacles, and a method that resensitizes pathogens to approved antibiotics therefore holds key advantages. We present a proof of principle for a system that restores antibiotic efficiency by.Read More
The present paper is focused on activity and resistance, whereas the companion review deals with nephrotoxicity (ototoxicity has been reviewed earlier in this journal ). In both reviews, we did not attempt to be exhaustive in any of these domains, and the material presented has been selected on the basis of its interest in terms of new concepts or because it deals directly with the design of.Read More
Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance Alita R. Burmeistera,b,1, Abigail Fortiera,b, Carli Rousha, Adam J. Lessinga,b, Rose G. Bendera,b, Roxanna Barahmana,b, Raeven Granta, Benjamin K. Chana, and Paul E. Turnera,b,c,1 aDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520; bBEACON Center for the Study of.Read More
While antibiotic resistance in animal or food isolates has been investigated in detail, research on resistance gene transfer from the farm to the environment is only advancing during the past years. Main sources of resistance at farm level are the application of animal manure to agricultural soils and leakage from manure lagoons. This review is on literature mostly from the past three years.Read More
Plasmid-mediated multidrug resistance is one of the most upcoming problems in the treatment of infectious diseases, as bacteria have reached the resistance to most of the antibiotics that are available for treatment. Plasmids are extrachromosomal pieces of double stranded DNA which multiply independently inside the bacteria (Trevors et al., 1985). Antibiotic resistance in bacteria may be an.Read More
There is a long-standing debate over the exact role that agricultural use of antimicrobials plays in the current antibiotic resistance crisis. 59 Although data gaps complicate the debate somewhat, 60,61 existing evidence proves that part of the crisis is caused by antimicrobial use in livestock. 62 Experience in Europe shows that changing animal husbandry practices and removing growth.Read More
Antibiotic resistance has been increasing along with antibiotic use. At the same time, the supply of new drugs to replace those rendered inefficient by the development has been dwindling, leading to concerns that we may soon lack efficient means to treat bacterial infections. Though the problem has received considerable interest, there are no indications that the situation is about to change.Read More
The origin of bacteria resistance to antibiotics can either be chromosomal or extra-chromosomal (plasmid mediated) and one way of determining the origin of bacterial drug resistance is by plasmid elimination. In this study, the antibiotic susceptibility of seven Escherichia coli isolates (numbered 1-7) from urine and stool samples, were assessed using the disk diffusion method.Read More
Antibiotic resistance of bacteria and other microorganisms is one of the most serious and grievous challenges of the twenty-first century. The life-saving drugs, which held a great deal of promises during the 1940s to eradicate all the infectious life-threatening diseases in the world, have ceased to work, because of the increasing emergence of microbial strains invulnerable to them.Read More
The inhibitory activity of a semipure fraction from the plant, Acalypha wilkesiana assigned as 9EA-FC-B, alone and in combination with ampicillin, was studied against methicillin-resistant Staphylococcus aureus (MRSA). In addition, effects of the combination treatment on PBP2a expression were investigated. Microdilution assay was used to determine the minimal inhibitory concentrations (MIC).Read More